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High-Resolution Hyperpolarized J‑Spectra with Parahydrogen Discrimination

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journal contribution
posted on 16.12.2015, 23:55 by I. Prina, L. Buljubasich, R. H. Acosta
Parahydrogen-induced polarization (PHIP) has become a powerful tool not only to overcome the low intrinsic sensitivity of nuclear magnetic resonance (NMR) but also as a probe for catalytic reactions, as a contrast agent in magnetic resonance imaging (MRI), or in analytic chemistry. In complex systems, the antiphase signals coming from parahydrogen in a PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) experiment can be partially canceled by the presence of large thermally polarized signals. In the present work, we present a simple method to separate the thermal and hyperpolrized contributions by taking advantage of their very different evolution during a modified CPMG sequence. The separation is obtained in combination with a property of the fast Fourier transform algorithm (FFT). The technique is experimentally demonstrated for a mixture of hyperpolarized 1-hexene and a large amount of CH2Cl2.