High Density Glycopolymers Functionalized Perylene Diimide Nanoparticles for Tumor-Targeted Photoacoustic Imaging and Enhanced Photothermal Therapy
journal contributionposted on 29.08.2017, 00:00 by Pengfei Sun, Pengcheng Yuan, Gaina Wang, Weixing Deng, Sichao Tian, Chao Wang, Xiaomei Lu, Wei Huang, Quli Fan
Near-infrared (NIR) absorbing nanoagents with functions of photoacoustic imaging (PAI) and photothermal therapy (PTT) have received great attention for cancer therapy. However, endowing them with multifunctions, especially targeting ability, for enhancing in vivo PAI/PTT generally suffers from the problems of synthetic complexity and low surface density of function groups. We herein report high density glycopolymers coated perylenediimide nanoparticles (PLAC–PDI NPs), self-assembled by poly(lactose)-modified perylenediimide (PLAC–PDI), as tumor-targeted PAI/PTT nanoagents. Atom transfer radical polymerization and click reaction were used in sequence to prepare PLAC–PDI, which can accurately control the content of poly(lactose) (PLAC) in PLAC–PDI and endow PLAC–PDI NPs with high density PLAC surface. The high density PLAC surface provided NPs with long-time colloidal stability, outstanding stability in serum and light, and specific targeting ability to cancer cells and tumors. Meanwhile, PLAC–PDI NPs also presented high photothermal conversion efficiency of 42% by virtue of strong π–π interactions among perylenediimide molecules. In living mice, PAI experiments revealed that PLAC–PDI NPs exhibited effective targeting ability and enhanced PTT efficacy to HepG2 tumor compared with control groups, lactose blocking, and ASGP-R negative tumor groups. Overall, our work provids new insights for designing glycopolymers-based therapeutic nanoagents for efficient tumor imaging and antitumor therapy.
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control groupsEnhanced Photothermal Therapy Near-infraredantitumor therapywork providsphotoacoustic imagingclick reactionTumor-Targeted Photoacoustic Imagingperylenediimide moleculesAtom transferphotothermal conversion efficiencyNIRsurface densitycancer cellstumor imagingperylenediimide nanoparticlesHepG 2 tumortumor groupsphotothermal therapyASGP-Rdensity PLAC surfaceNPdensity glycopolymersHigh Density Glycopolymers Functionalized Perylene Diimide NanoparticlesPTT efficacyfunction groupsPAI experimentscancer therapy