op1c00313_si_001.pdf (1.52 MB)
High-Throughput Experimentation Enabling Rapid Process Optimization of an RSV Drug Candidate
journal contributionposted on 2021-11-02, 15:17 authored by Xavier Jusseau, Ed Cleator, William M. Maton, Qinghao Chen, Robert Geertman, Yuanyuan Yuan, Xiaowei Wang, Haojuan Wei, Florian Medina, Massimo Giannerini
The process optimization for the synthesis of an RSV antiviral agent is described. Key to the identification of these optimal conditions was the use of high-throughput experimentation to greatly reduce the development time and realize significant process improvements in key steps such as the telescoped pyrazolopyrimidine core assembly and the borylation/Suzuki sequence.