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Download fileHeterogeneous Phase Transfer Catalysis in Solid Phase Syntheses of Anth-Cyclic Tetrapeptides
journal contribution
posted on 2016-08-23, 18:20 authored by Dongyue Xin, Jian Yuan, Kwok-Yin Wong, Kevin BurgessThis study features
solid phase syntheses of cyclic tetrapeptides
containing anthranilic acid (Anth) on relatively
inexpensive resins derived from polystyrene. It proved to be difficult
to hydrolyze a supported Anth-methyl ester unless a phase transfer catalyst was added to facilitate
transport of hydroxide into the swollen hydrophobic gel state of the
resin. We suggest this may be an under-appreciated strategy for improving
syntheses on polystyrene supports.