posted on 2024-06-27, 13:03authored byDeeksha, Ritesh Singh
Herein, we report the first general approach to access N-alkoxy-2,2-difluoro indoxyls, via formal 3 + 2 cycloaddition
of aryne and (putative) fluorinated-aza-oxyallyl cation. This transition-metal/oxidant-free
transformation occurs under mild reaction conditions with a short
reaction time. Mechanistic investigation indicates the possible involvement
of the closed form of fluorinated-aza-oxyallyl cation, viz., α-lactam,
in the current transformation.