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Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

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journal contribution
posted on 28.02.2014, 00:00 by Wenjun Zhang, Sumei Li, Yiguang Zhu, Yuchan Chen, Yaolong Chen, Haibo Zhang, Guangtao Zhang, Xinpeng Tian, Yu Pan, Si Zhang, Weimin Zhang, Changsheng Zhang
Three new macrolactams, heronamides D–F (13), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D–F (13) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A–C. The relative configurations of 13 were deduced by detailed analysis of 3JHH values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher’s method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.