Heparin Mimic Material Derived from Cellulose Nanocrystals
journal contributionposted on 14.02.2020, 13:08 by Zahra J. Gallagher, Sara Fleetwood, Terence L. Kirley, Maureen A. Shaw, Eric S. Mullins, Neil Ayres, E. Johan Foster
This study analyzes and evaluates the use of cellulose nanocrystals (CNCs), stiff nanosized natural materials that have been modified to mimic heparin. These CNCs are simple polysaccharides with a similar backbone structure to heparin, which when modified reduces coagulation and potentially the long-term effects of solution-based anticoagulants. Thus, CNCs represent an ideal foundation for generating materials biocompatible with blood. In this study, we developed a biocompatible material that inhibits blood clotting through surface functionalization to mimic heparin. Surface chemistry of CNCs was modified from “plain” CNCs (70 mmol SO3–/kg) to 500 mmol COO–/kg (TEMPO-oxidized CNCs) and 330 mmol SO3–/kg CNCs (sulfonated CNCs). Platelet adherence and blood assays show that changes in functionalization reduce coagulation. By utilizing and modifying CNCs reactive functional groups, we create a material with unique and favorable mechanical properties while also reducing clotting.
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TEMPO-oxidized CNCsblood assays showCOOsolution-based anticoagulantsSurface chemistryCellulose Nanocrystals330 mmolHeparin Mimic Material Derivedsurface functionalizationmaterials biocompatiblePlatelet adherencebiocompatible materialbackbone structuresulfonated CNCsCNCs reactivecellulose nanocrystals