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Hectochlorin and Morpholine Derivatives from the Thai Sea Hare, Bursatella leachii

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journal contribution
posted on 24.06.2005, 00:00 by Suchada Suntornchashwej, Narongsak Chaichit, Minoru Isobe, Khanit Suwanborirux
Investigation of the EtOAc extract from the Thai sea hare, Bursatella leachii, resulted in the isolation of a potent stimulator of actin assembly, hectochlorin (1), and its new derivative, deacetylhectochlorin (2). Compound 2 exhibited more potent cytotoxicity than 1 against different human carcinoma cell lines. In addition, a new morpholine-2,5-dione analogue, syn-3-isopropyl-6-(4-methoxybenzyl)-4-methylmorpholine-2,5-dione (3), was co-isolated.