American Chemical Society
ol3c02657_si_001.pdf (2.19 MB)

Hard–Soft Cooperativity of an Allosteric Tweezer

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journal contribution
posted on 2023-09-25, 19:47 authored by Suk-il Kang, Hyun Lee, Sungryul Bae, Dongwhan Lee
Drawing inspiration from allosteric proteins, a zigzag-shaped π-conjugation was structurally engineered into a tweezer-like ionophore having multiple disparate binding sites. When a soft metal ion binds to the central tridentate ligand motif, the rigid backbone folds, bringing two macrocyclic arms into close proximity. Stabilized by a coordinating anion, the tweezer-like conformation of the resulting metalloligand recruits a hard cation to form a sandwich-like complex with a remarkably enhanced binding affinity and selectivity.