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Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge Phorbas gukulensis

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journal contribution
posted on 23.04.2010, 00:00 by Su Young Park, Hyukjae Choi, Hoosang Hwang, Heonjoong Kang, Jung-Rae Rho
Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05−0.80 μM.