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Guaiane Sesquiterpene Lactones and Amino Acid-Sesquiterpene Lactone Conjugates from the Aerial Parts of Saussurea pulchella

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journal contribution
posted on 25.04.2008, 00:00 by Min Cheol Yang, Sang Un Choi, Wahn Soo Choi, Sun Yeou Kim, Kang Ro Lee
Two new guaiane sesquiterpene lactones (1 and 2) and seven new amino acid-sesquiterpene lactone conjugates (39), together with six known sesquiterpene lactones (1015), were isolated from the methanol extract of the aerial parts of Saussurea pulchella. Their structures were determined on the basis of spectroscopic and chemical methods to be 8α-O-(3′-hydroxy-3′-methylbutyryl)desacylcynaropicrin (1), 8α-O-(2′, 3′-dihydroxyisobutyryl)11β,13-dihydrodesacylcynaropicrin (2), and pulchellamines A, B, C, D, E, F, and G (39). The structures of the new amino acid-sesquiterpene lactone conjugates, pulchellamines A, B, C, D, E, F, and G (39), were confirmed by synthesis. The isolated compounds were evaluated for cytotoxic activity against four human tumor cell lines. Compounds 11 and 12 exhibited cytotoxicity against skin melanoma (SK-MEL-2) and ovary malignant ascites (SK-OV-3) human tumor cell lines with ED50 values of 1.53 and 4.07 µM, and 2.49 and 7.42 µM, respectively.