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Grassypeptolides F and G, Cyanobacterial Peptides from Lyngbya majuscula

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journal contribution
posted on 26.08.2011, 00:00 authored by Wendy L. Popplewell, Ranjala Ratnayake, Jennifer A. Wilson, John A. Beutler, Nancy H. Colburn, Curtis J. Henrich, James B. McMahon, Tawnya C. McKee
Grassypeptolides F (1) and G (2), bis-thiazoline-containing cyclic depsipeptides with a rare β-amino acid, extensive N-methylation, and a large number of d-amino acids, are reported from an extract of the Palauan cyanobacterium Lyngbya majuscula. Both 1 and 2 were found to have moderate inhibitory activity against the transcription factor AP-1 (IC50 = 5.2 and 6.0 μM, respectively).