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Download fileGold-Catalyzed Tandem [3,3]-Propargyl Ester Rearrangement Leading to (E)‑1H‑Inden-1-ones
journal contribution
posted on 2014-01-03, 00:00 authored by Li-Jing Wang, Hai-Tao Zhu, An-Qi Wang, Yi-Feng Qiu, Xue-Yuan Liu, Yong-Min LiangAn efficient method for the synthesis
of (E)-1H-inden-1-ones using gold-catalyzed
tandem [3,3]-propargyl
ester rearrangement followed by Michael addition under mild reaction
conditions has been developed. The resulting products are important
frameworks found in numerous natural products and pharmaceutically
active compounds, as well as being valuable intermediates in organic
synthesis.