Gold-Catalyzed Hydration of Haloalkynes to α‑Halomethyl Ketones
journal contributionposted on 20.09.2013, 00:00 by Longyong Xie, Yundong Wu, Weiguo Yi, Lei Zhu, Jiannan Xiang, Weimin He
A general atom-economical approach for the synthesis of α-halomethyl ketones is demonstrated through hydration of a wide range of haloalkynes. Other outstanding features include excellent yields from both alkyl- and aryl-substituted haloalkynes and wide functional group tolerance. This protocol is an alternative to conventional α-halogenation of ketones.