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Gold-Catalyzed Benzannulation of 3-Alkoxy-1,5-enynes: Access to Functionalized Benzenes

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journal contribution
posted on 07.05.2010, 00:00 by Guijie Li, Yuanhong Liu
A cationic Au(I) complex catalyzed benzannulation of 3-alkoxy-1,5-enynes bridged by a cyclopropyl ring with a variety of nucleophiles is described. The reaction occurs selectively through a 6-endo-dig pathway to provide tri- and tetrasubstituted benzenes efficiently under mild reaction conditions.