Generation of Indoles with Agrochemical Significance through Biotransformation by Chaetomium globosum
journal contributionposted on 22.07.2019, 16:42 by Wei Yan, Shuang Shuang Zhao, Yong Hao Ye, Yang Yang Zhang, Yue Zhang, Jia Yun Xu, Sheng Mei Yin, Ren Xiang Tan
Six new (1–6) and two known (7 and 8) indole alkaloids were produced by the marine fish-derived fungus Chaetomium globosum 1C51 through biotransformation. The structures of these alkaloids were elucidated by a combination of MS, NMR, and X-ray crystallography analyses. Chaetoindolone A (1) was shown to inhibit the growth of the rice-pathogenic bacteria Xanthomonas oryzae pv. oryzae (xoo) both in vitro and in vivo. Chaetogline A (7) was found to be fungicidal against Sclerotinia sclerotiorum, a pathogen causing rape sclerotinia rot. Collectively, this work provides access to new indole alkaloids with potential agrochemical significance.