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Generation of Aza-ortho-xylylenes via Ring Opening of 2-(2-Acylaminophenyl)aziridines:  Application in the Construction of the Communesin Ring System

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journal contribution
posted on 31.08.2006, 00:00 authored by Seth L. Crawley, Raymond L. Funk
A new protocol for generating aza-ortho-xylylenes via acid-catalyzed or fluoride-promoted ring opening of 2-(2-acylaminophenyl)aziridines is described. This methodology has been exploited in the rapid construction of a hexacyclic substructure of communesin B.