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General and Chemoselective Bisphosphonylation of Secondary and Tertiary Amides

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journal contribution
posted on 06.02.2015, 00:00 by Ai-E Wang, Zong Chang, Wei-Ting Sun, Pei-Qiang Huang
With Tf2O as the activation reagent, a mild and general method has been developed for the bisphosphonylation of both secondary and tertiary amides. The protocol is highly efficient and chemoselective, and it tolerates a number of sensitive functional groups such as cyano, ester, and aldehyde groups.