General Synthetic Approach to Functionalized Dihydrooxepines

Nicolaou, K. C.; Yu, Ruocheng; Shi, Lei; Cai, Quan; Lu, Min; Heretsch, Philipp

doi:10.1021/ol4006689.s001

General Synthetic Approach to Functionalized Dihydrooxepines

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posted on 2013-04-19, 00:00 authored by K. C. Nicolaou, Ruocheng Yu, Lei Shi, Quan Cai, Min Lu, Philipp Heretsch

A three-step sequence to access functionalized 4,5-dihydrooxepines from cyclohexenones has been developed. This approach features a regioselective Baeyer–Villiger oxidation and subsequent functionalization via the corresponding enol phosphate intermediate.

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approach features sequence Approach regioselective functionalized access Functionalized DihydrooxepinesA functionalization dihydrooxepine cyclohexenone oxidation Baeyer enol phosphate General

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General Synthetic Approach to Functionalized Dihydrooxepines

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