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Ganolearic Acid A, a Hexanorlanostane Triterpenoid with a 3/5/6/5-Fused Tetracyclic Skeleton from Ganoderma cochlear
journal contribution
posted on 2018-10-22, 12:36 authored by Xing-Rong Peng, Yan-Jie Huang, Shuang-Yang Lu, Jing Yang, Ming-Hua QiuGanolearic acid A (1), a 3,4-seco-hexanortriterpenoid featuring a rare
3/5/6/5 tetracyclic system, was obtained in trace amounts from Ganoderma cochlear by a LC-UV/MS-guided method. Meanwhile,
a new 3,4-seco-nortriterpenoid, fornicatin M (2), as well as its biogenetic precursor, fornicatin D (3), was isolated. The stereochemical structure of 1 was completely established by 1D, 2D NMR, IR, and HRMS spectra,
as well as 13C NMR and electronic circular dichroism calculations.
The plausible biogenetic pathway of 1 and 2 was proposed. Furthermore, their anti-inflammatory activities were
evaluated.
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Ganoderma cochlear Ganolearic acidFusedfornicatin Manti-inflammatory activitiesHexanorlanostane Triterpenoidfornicatin Dsecodichroism calculationshexanortriterpenoid13 C NMR1 DGanoderma cochlearLC-UVIRTetracyclicbiogenetic pathwaybiogenetic precursorstereochemical structureSkeletonHRMS spectratrace amountsnortriterpenoidtetracyclicmethod2 D NMR
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