Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes
journal contributionposted on 29.06.2016, 17:21 by Jie Pan, Bethany I. Harriss, Chi-Fai Chan, Lijun Jiang, Tik-Hung Tsoi, Nicholas J. Long, Wing-Tak Wong, Wai-Kwok Wong, Ka-Leung Wong
A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.