Gallium and Functionalized-Porphyrins Combine to Form
Potential Lysosome-Specific Multimodal Bioprobes

Pan, Jie; Harriss, Bethany I.; Chan, Chi-Fai; Jiang, Lijun; Tsoi, Tik-Hung; Long, Nicholas J.; Wong, Wing-Tak; Wong, Wai-Kwok; Wong, Ka-Leung

doi:10.1021/acs.inorgchem.6b01159.s001

Gallium and Functionalized-Porphyrins Combine to Form Potential Lysosome-Specific Multimodal Bioprobes

https://doi.org/10.1021/acs.inorgchem.6b01159.s001
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journal contribution

posted on 2016-06-29, 17:21 authored by Jie Pan, Bethany I. Harriss, Chi-Fai Chan, Lijun Jiang, Tik-Hung Tsoi, Nicholas J. Long, Wing-Tak Wong, Wai-Kwok Wong, Ka-Leung Wong

A water-soluble bimetallic normal (“cold”) and radiochemical (“hot”) gallium–porphyrin–ruthenium–bipyridine complex (GaporRu-1) has been synthesized by microwave methodology in short reaction times with good (>85%) yields. 68GaporRu-1 is demonstrated to be a potential multimodal and functional bioprobe for positron emission tomography (PET), lysosome specific optical imaging, and photodynamic therapy.