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Functionalized Chiral Ionic Liquid Catalyzed Enantioselective Desymmetrizations of Prochiral Ketones via Asymmetric Michael Addition Reaction

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journal contribution
posted on 23.11.2007, 00:00 by Sanzhong Luo, Long Zhang, Xueling Mi, Yupu Qiao, Jin-Pei Cheng
Functionalized chiral ionic liquids were found to be highly effective and reusable organocatalysts for asymmetric Michael additions of 4-substituted cyclohexanones. The desymmetrization reaction afforded the desired Michael adducts bearing three carbon stereocenters with up to 99% ee.