ab9b01916_si_001.pdf (185.59 kB)
Functionalized Carbon Nanotube-Embedded Poly(vinyl alcohol) Microspheres for Efficient Removal of Tumor Necrosis Factor‑α
journal contribution
posted on 2020-07-02, 21:44 authored by Jian Chen, Lichun Wang, Tingting Wang, Chunran Li, Wenyan Han, Yamin Chai, Zhuang Liu, Lailiang Ou, Wenzhong LiTumor
necrosis factor (TNF)-α has an important role in the
pathogenesis of autoimmune and inflammatory diseases such as rheumatoid
and septic arthritis. Removal of excess tumor necrosis factor-α
(TNF-α) is a promising treatment. In this study, a series of
functionalized carbon nanotube-embedded poly(vinyl alcohol) (PVA)
nanocomposite adsorbents were prepared for TNF-α removal for
the first time. The resulting nanocomposites were characterized by
scanning electron microscopy and Raman spectroscopy, which demonstrated
that carbon nanotubes were well-dispersed on the surface of PVA macroporous
microspheres. Adsorption tests showed that the carboxylated carbon
nanotube-embedded composite microspheres (PVA/MWCNTs-COOH) possessed
much better adsorption capacity for TNF-α in both simulated
serum solution and rat plasma compared to the aminated (PVA/MWCNTs-NH2) and raw carbon nanotube-embedded microspheres (PVA/MWCNTs-raw).
In addition, the effects on hemolytic activity, the anticoagulant
property, and the components of blood were negligible, indicating
the excellent blood compatibility of composite beads. Our findings
suggest that the carboxylated carbon nanotube-embedded composite microspheres
may be potentially useful for the treatment of autoimmune and inflammatory
diseases by removing TNF-α from the blood.