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Free-Amine Directed Arylation of Biaryl-2-amines with Aryl Iodides by Palladium Catalysis

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journal contribution
posted on 06.09.2013, 00:00 by Zunjun Liang, Ruokun Feng, Hong Yin, Yuhong Zhang
A new palladium-catalyzed free-amine directed arylation of C(sp2)–H bonds in the presence of AgOAc and TFA is described. Biaryl-2-amines react with various aryl iodides to give the corresponding mono- or diarylated products with exclusive regioselectivity.