Free-Radical Triggered Ordered Domino Reaction: An Approach to C–C Bond Formation via Selective Functionalization of α‑Hydroxyl-(sp3)C–H in Fluorinated Alcohols
posted on 2016-08-25, 14:01authored byZhengbao Xu, Zhaojia Hang, Zhong-Quan Liu
A free-radical mediated highly ordered
radical addition/cyclization/(sp3)C–C(sp3) formation domino reaction is developed.
Three new C–C bonds are formed one by one in a mixed system.
Furthermore, it represents the first example of cascade C–C
bond formation via selective functionalization of α-hydroxyl-C(sp3)–H in fluorinated alcohols.