Formation of Chiral Quaternary Carbon Stereocenters Using Silylene Transfer Reactions:  Enantioselective Synthesis of (+)-5-epi-Acetomycin

Chiral quaternary carbon stereocenters can be established with high diastereoselectivity by a silylene transfer/Ireland−Claisen rearrangement. The utility of this method was demonstrated by application to a synthesis of (+)-5-epi-acetomycin.