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Formal Total Synthesis of (±)-Strictamine Based on a Gold-Catalyzed Cyclization

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journal contribution
posted on 24.03.2016, 13:47 by Daisuke Nishiyama, Ayako Ohara, Hiroaki Chiba, Hiroshi Kumagai, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
A gold-catalyzed cyclization of 1-propargyl-1,2,3,4-tetrahydro-β-carboline led to formation the D-ring of strictamine. Functional group modifications of the resulting tetracyclic indolenine led to the formal total synthesis of (±)-strictamine.

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