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Formal Total Synthesis of (+)-Gephyrotoxin

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journal contribution
posted on 15.08.2008, 00:00 authored by Marco Santarem, Corinne Vanucci-Bacqué, Gérard Lhommet
An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine β-enamino ester obtained by condensation of (S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.