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Download fileFormal Synthesis of ent-Cephalotaxine Using a One-Pot Parham–Aldol Sequence
journal contribution
posted on 2018-07-17, 00:00 authored by Juha H. Siitonen, Lu Yu, Jakob Danielsson, Giovanni Di Gregorio, Peter SomfaiA short
formal synthesis of ent-Cephalotaxine
is achieved. The approach features a new Lewis acid-mediated [2,3]-Stevens
rearrangement of N-allylated prolineamide to generate
a key quaternary stereogenic center. Additionally, a one-pot Parham–aldol
sequence was developed to rapidly assemble two of the four rings in
the cephalotaxine core.