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Fluorous TBAF: A Convenient and Selective Reagent for Fluoride-Mediated Deprotections

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journal contribution
posted on 21.08.2009, 00:00 by Santos Fustero, Amador García Sancho, José Luis Aceña, Juan F. Sanz-Cervera
A fluorous analogue of TBAF has been developed for its use in the clean removal of silicon-derived protecting groups. Purification of the crude mixtures by fluorous solid-phase extractions allowed alcohols, amines, and carboxylic acids to be obtained in high purity, with no need of chromatographic separations. The moderate reactivity of fluorous TBAF was exploited in selective deprotections of several bifunctional molecules.

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