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Fluoro, Alkylsulfanyl, and Alkylsulfonyl Leaving Groups in Suzuki Cross-Coupling Reactions of Purine 2‘-Deoxynucleosides and Nucleosides

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journal contribution
posted on 17.03.2005, 00:00 by Jiangqiong Liu, Morris J. Robins
Protected 2‘-deoxynucleoside and nucleoside derivatives of 6-fluoropurine, 6-(3-methylbutyl)sulfanylpurine, and 6-(3-methylbutyl)ylsulfonylpurine undergo nickel- or palladium-mediated C−C cross-coupling with arylboronic acids to give good yields of 6-arylpurine products.

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