American Chemical Society
ol050063s_si_002.pdf (4.37 MB)

Fluoro, Alkylsulfanyl, and Alkylsulfonyl Leaving Groups in Suzuki Cross-Coupling Reactions of Purine 2‘-Deoxynucleosides and Nucleosides

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journal contribution
posted on 2005-03-17, 00:00 authored by Jiangqiong Liu, Morris J. Robins
Protected 2‘-deoxynucleoside and nucleoside derivatives of 6-fluoropurine, 6-(3-methylbutyl)sulfanylpurine, and 6-(3-methylbutyl)ylsulfonylpurine undergo nickel- or palladium-mediated C−C cross-coupling with arylboronic acids to give good yields of 6-arylpurine products.