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Flueggines A and B, Two New Dimeric Indolizidine Alkaloids from Flueggea virosa

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journal contribution
posted on 05.08.2011, 00:00 by Bing-Xin Zhao, Ying Wang, Dong-Mei Zhang, Ren-Wang Jiang, Guo-Cai Wang, Jun-Min Shi, Xiao-Jun Huang, Wei-Min Chen, Chun-Tao Che, Wen-Cai Ye
Two unprecedented C,C-linked dimeric indolizidine alkaloids, flueggines A (1) and B (2), were isolated from the twigs and leaves of Flueggea virosa. The structures and absolute configurations were elucidated by means of NMR, single-crystal X-ray diffraction, and CD analyses. Compound 1 is the first example of Securinega alkaloids bearing an isoxazolidine ring, the plausible biogenetic pathway of which is also proposed. Compound 2 exhibited growth inhibitory activity against MCF-7 and MDA-MB-231 human breast cancer cells.