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First Synthesis of C. difficile PS-II Cell Wall Polysaccharide Repeating Unit

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journal contribution
posted on 04.02.2011, 00:00 by Elisa Danieli, Luigi Lay, Daniela Proietti, Francesco Berti, Paolo Costantino, Roberto Adamo
Clostridium difficile is the most commonly diagnosed cause of nosocomial diarrhea with increasing incidence and mortality among elderly and hospitalized patients. We report the first synthesis of the surface polysaccharide PS-II repeating unit and its nonphosphorylated analogue, with a linker for conjugation, via a (4 + 2) convergent approach from a common AB(D)C tetrasaccharide intermediate.