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First Desymmetrization of 1,3-Propanediamine Derivatives in Organic Solvent. Development of a New Route for the Preparation of Optically Active Amines§

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journal contribution
posted on 2007-10-11, 00:00 authored by Eduardo Busto, Vicente Gotor-Fernández, Jose Montejo-Bernardo, Santiago García-Granda, Vicente Gotor
The chemical synthesis and enzymatic desymmetrization of a panel of prochiral diamines have been successfully described for the first time using lipases in organic solvents. A family of 2-aryl-1,3-propanediamines has been obtained with high enantiopurity and good yields in the PSL-catalyzed reaction using diallyl carbonate in 1,4-dioxane.