bc6b00298_si_001.pdf (699.99 kB)
First Crystal Structure for a Gold Carbene–Protein Adduct
journal contribution
posted on 2016-06-30, 00:00 authored by Giarita Ferraro, Chiara Gabbiani, Antonello MerlinoThe X-ray structure of the adduct
formed in the reaction between
the gold N-heterocyclic carbene compound Au(NHC)Cl (with NHC = 1-butyl-3-methyl-imidazole-2-ylidene)
and the model protein thaumatin is reported here. The structure reveals
binding of Au(NHC)+ fragments to distinct protein sites.
Notably, binding of the gold compound occurs at lysine side chains
and at the N-terminal tail; the metal binds the protein after releasing
Cl– ligand, but retaining NHC fragment.