American Chemical Society
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Ferrocenylphosphines as New Catalysts for Baylis−Hillman Reactions

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journal contribution
posted on 2005-11-25, 00:00 authored by Susana Isabel Pereira, Javier Adrio, Artur M. S. Silva, Juan Carlos Carretero
Readily available ferrocenyldialkylphosphines are effective air-stable catalysts for Baylis−Hillman reaction between aldehydes and acrylates, affording the corresponding adducts in high yields and short reaction times. A set of readily accessible planar chiral ferrocenyldialkylphosphines have been tested in asymmetric Baylis−Hillman reactions. The best enantioselectivities were obtained using Mandyphos as chiral catalyst (up to 65% ee).