Fe(OTf)3- and γ‑Cyclodextrin-Catalyzed
Hydroamination of Alkenes with Carbazoles

Xiao, En-Kai; Wu, Xian-Tao; Ma, Feng; Feng, Xiaohua; Chen, Peng; Jiang, Yi-Jun

doi:10.1021/acs.orglett.0c03959.s001

ol0c03959_si_001.pdf (5.22 MB)

Fe(OTf)₃- and γ‑Cyclodextrin-Catalyzed Hydroamination of Alkenes with Carbazoles

journal contribution

posted on 2020-12-23, 21:44 authored by En-Kai Xiao, Xian-Tao Wu, Feng Ma, Xiaohua Feng, Peng Chen, Yi-Jun Jiang

A Fe(OTf)₃- and γ-cyclodextrin catalyzed hydroamination of alkenes with carbazoles is demonstrated. This biomimetic-catalyst-oriented sustainable and green method could deliver a wide scope of N-alkylated carbazoles and N-alkylated-carbazole-fused aromatics in up to 97% yield. The salient features of this transformation include simple and benign reaction conditions with no need for a strong base, additive, or the irradiation of light.