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Factors Controlling Reactivity in the Hydrogen Atom Transfer and Radical Addition Steps of a Radical Relay Cascade

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journal contribution
posted on 15.07.2019, 11:37 by Yike Zou, Xiao-Song Xue, Yifan Deng, Amos B. Smith, K. N. Houk
DFT exploration of 1,5- and 1,6-hydrogen atom transfers (HAT), radical addition, and relay to alkene is reported. The reactivity of 1,5- and 1,6-HAT are similar. We also explored reactions involving a multiple radical transferring process. Initially generated radicals undergo a multiple HAT process to form multiple bonds in a “relay” fashion, provided by exquisitely balanced rates.