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Facile and Rapid Access to Glyconanocapsules by CuAAC Interfacial Polyaddition in Miniemulsion Conditions

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journal contribution
posted on 2012-08-21, 00:00 authored by Rémi Roux, Ludovic Sallet, Pierre Alcouffe, Stéphane Chambert, Nathalie Sintes-Zydowicz, Etienne Fleury, Julien Bernard
Glyconanocapsules with a biocompatible oily core have been successfully prepared by copper­(I)-catalyzed azide–alkyne cycloaddition (CuAAC) interfacial step growth polymerization between 6,6′-diazido-6,6′-dideoxysucrose and bis­(propargyloxy)­butane in oil-in-water miniemulsion conditions. Optimization of the interfacial polymerization process in dispersed medium afforded the rapid and reproducible preparation of stable monodispersed glyconanocapsules having a diameter around 200 nm.

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