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Facile and Efficient Synthesis of Carbohybrids as Stereodivergent Druglike Small Molecules

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journal contribution
posted on 18.04.2008, 00:00 by Ram Sagar, Seung Bum Park
A facile and efficient one-pot synthesis of acyclic polyols fused with pyrazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]pyrimidines as novel carbohybrids with regioselectivity was achieved through the condensation of 2-C-formyl glycals with 3-aminopyrazoles and 3-amino-1,2,4-triazoles in excellent yields under the microwave irradiation.