posted on 2003-07-10, 00:00authored byScott M. Capitosti, Todd P. Hansen, Milton L. Brown
A five-step synthesis of an azido-thalidomide analogue is presented. The sequence requires cheap and readily available starting materials and
reagents, and only two steps require purification. Additionally, the azido-labeled analogue possesses activity comparable to that of thalidomide
in inhibiting the proliferation of human microvascular endothelial cells, thus providing impetus for its use as a potential photoaffinity label of
thalidomide.