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Facile Synthesis of Raman Active Phospholipid Gold Nanoparticles

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journal contribution
posted on 15.12.2010, 00:00 by Natalie C. M. Tam, Benjamin M. T. Scott, Danut Voicu, Brian C. Wilson, Gang Zheng
Gold nanoparticle-based surface-enhanced Raman scattering (SERS) probes have shown promise for disease detection and diagnosis. To improve their structural and functional stability for in vivo applications, we synthesized a colloidal SERS gold nanoparticle that encapsulates Raman molecules adsorbed on 60 nm gold with a nonthiol phospholipid coating. Transmission electron microscopy and Raman and UV spectroscopy validated its reproducibility and stability. This novel lipid-based SERS probe provides a viable alternative to the PEGylation and silica coating strategies.