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Facile Synthesis of Azaarene-Substituted 3-Hydroxy-2-oxindoles via Brønsted Acid Catalyzed sp3 C–H Functionalization

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journal contribution
posted on 03.02.2012, 00:00 by Rui Niu, Jian Xiao, Tao Liang, Xingwei Li
Brønsted acid catalyzed functionalization of sp3 C–H bonds in 2-methyl azaarenes has been achieved in the reaction with isatins. This method provides facile synthesis of biologically important azaarene-substituted 3-hydroxy-2-oxindoles in one step in moderate to good yields.