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Facile Preparation of 3-Substituted Benzisothiazoles from o-Mercaptoacylphenones

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journal contribution
posted on 19.02.2010, 00:00 by Nelmi O. Devarie-Baez, Ming Xian
A synthesis of 3-substituted benzisothiazoles starting from readily available o-mercaptoacylphenones is presented. The key cyclization step features a mild S-nitrosation and its succeeding intramolecular aza-Wittig reaction leading to the construction of the title compounds.