ol0166855_si_001.pdf (37.18 kB)

Facile Acylation of Sterically Hindered Alcohols through Ketene Intermediates

Download (37.18 kB)
journal contribution
posted on 23.10.2001, 00:00 by Moshe Nahmany, Artem Melman
Carboxylic acids possessing strongly electron withdrawing substituents in the α-position in the presence of DCC acylate sterically hindered and chemically sensitive alcohols. The pattern of reactivity, the deuteration experiments, and the formation of a product derived from a [4 + 2] cycloaddition reaction corroborate the existence of ketene intermediates in the reaction.