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Fabrication of Core–Shell-Structured Organic–Inorganic Hybrid Nanocatalyst for the Expedient Synthesis of Polysubstituted Oxazoles via Tandem Oxidative Cyclization Pathway
journal contribution
posted on 2017-06-19, 13:33 authored by Sriparna Dutta, Shivani Sharma, Aditi Sharma, Rakesh K. SharmaThe quest for designing efficient
heterogeneous catalytic systems
for tandem oxidative cyclization reactions has provided a great impetus
to research efforts, as it enables the step-economic construction
of complex heterocyclic molecules as well as confers the benefits
of a facile catalytic recovery. In the present study, we disclose
a new core–shell-structured organic–inorganic hybrid
copper nanocatalyst fabricated via the covalent grafting of 2,2′-dipyridyl
ketone ligand on amine-functionalized silica-encapsulated magnetite
nanoparticles, followed by its metallation with cupric acetate for
the tandem oxidative cyclization of amines and β-ketoesters,
leading to the production of biologically active polysubstituted oxazole
moieties. This programmed catalytic protocol proceeds via the formation
of intermolecular C–C and C–N bonds by single-step synthesis
and accommodates a broad combination of reaction coupling partners.
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tandem oxidative cyclization reactionsdipyridylExpedient SynthesiscovalentsynthesisCoreimpetusrecoveryheterocyclic moleculesstep-economic constructionresearch effortsFabricationcorecopper nanocatalystOrganicaminescombinationHybridPolysubstituted OxazolesformationbenefitTandem Oxidative Cyclization Pathwayligandβ- ketoestersketoneprotocol proceedscupric acetatetandem oxidative cyclizationbondquestNanocatalystpolysubstituted oxazole moietiesmetallationamine-functionalized silica-encapsulated magnetite nanoparticles