posted on 2023-11-06, 14:00authored byYan Gong, Pei Wang, Ran Cao, Jiayingzi Wu, Haoran Ji, Mingsong Wang, Chuang Hu, Peng Huang, Xiansong Wang
Burns are among the most common causes of trauma worldwide.
Reducing
the healing time of deep burn wounds has always been a major challenge.
Traditional dressings not only require a lengthy medical procedure
but also cause unbearable pain and secondary damage to patients. In
this study, we developed an exudate-absorbing and antimicrobial hydrogel
with a curcumin-loaded magnesium polyphenol network (Cur-Mg@PP) to
promote burn wound healing. That hydrogel was composed of an ε-poly-l-lysine (ε-PLL)/polymer poly(γ-glutamic acid) (γ-PGA)
hydrogel (PP) and curcumin-loaded magnesium polyphenol network (Cur-Mg).
Because of the strong water absorption property of ε-PLL and
γ-PGA, Cur-Mg@PP powder can quickly absorb the wound exudate
and transform into a moist and viscous hydrogel, thus releasing payloads
such as magnesium ion (Mg2+) and curcumin (Cur). The released
Mg2+ and Cur demonstrated good therapeutic efficacy on
analgesic, antioxidant, anti-inflammation, angiogenesis, and tissue
regeneration. Our findings provide a strategy for accelerating burn
wound healing.