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Extending Pummerer Reaction Chemistry. Synthesis Studies in the Phakellin Alkaloid Area

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journal contribution
posted on 12.10.2007, 00:00 by Ken S. Feldman, Amanda P. Skoumbourdis, Matthew D. Fodor
The syntheses of (±)-dibromophakellstatin and, from this species, (±)-dibromophakellin are described. Oxidative cyclization of a phenylthiolated dihydrooroidin derivative triggered by a Pummerer reaction constitutes the key step in this biomimetic approach to this family of marine alkaloids.