jo061185g_si_001.pdf (2.22 MB)
Download fileExploration of the Mitsunobu Reaction with Tosyl- and Boc-Hydrazones as Nucleophilic Agents
journal contribution
posted on 2006-09-01, 00:00 authored by John M. Keith, Leslie GomezTosyl- and Boc-hydrazones were found to be effective
nucleophiles in the Mitsunobu reaction. Tosyl hydrazones
reacted cleanly with primary and secondary alcohols when
co-administered to a cooled DBAD/PPh3 or DEAD/PPh3
complex. Boc-hydrazones required electron-withdrawing
substituents to participate in the reaction.